England international winger Georgia Wilson scored five tries and kicked four goals for a memorable 28-point haul as Wigan Warriors ran in 11 tries total during a 52-8 demolition of Warrington Wolves.
Wilson crossed four times before the break as the Warriors raced into a 28-4 interval lead.
Vanessa Temple and Vicky Molyneux bagged a brace apiece and Rachel Thompson and Becky Greenfield also scored against opponents making their Super League debut.
Elsewhere, Leeds Rhinos started the 2021 Women's Super League season in style with a 68-16 victory over York City Knights.
The Rhinos enjoyed Grand Final and Challenge Cup success in 2019, but Covid-19 denied them the chance to defend their titles in 2020.
York led 10-4 early on and played their part with tries from captain Katie Langan and Ellie Hendry (2).
But the Rhinos were 24-10 ahead by half-time and eventually scored 13 tries through Courtney Winfield-Hill (2), Adi Akwiwu (2), Elle Frain (2), Ellie Oldroyd, Chloe Kerrigan, Hanna Butcher, Sophie Robinson, Ella Johnson, Aimee Staveley and Tara Moxon. Winfield-Hill also kicked 16 points.
St Helens signalled their intent with an 86-0 rout of Bradford Bulls.
Saints led 52-0 at the break and scored 15 tries with Jodie Cunningham, Amy Hardcastle and Carrie Roberts all claiming hat-tricks.
Emily Rudge and Danielle Bush went over twice each, while Faye Gaskin and Chantelle Crowl also crossed.
Kelsey Gentles claimed a first-half hat-trick as Castleford Tigers recorded a convincing 40-6 victory over Featherstone Rovers, their first success since Kirsty Moroney and Marie Colley took charge.
Gentles scored two tries in the first five minutes and added a third on the half-hour after Tamzin Renouf had got in on the act.
Hollie-Mae Dodd (2) and Grace Field added further tries with Leah Jones kicking 12 points.
