
Thursday - Leeds Rhinos v Hull FC - 8pm kick off on Sky Sports
Leeds will be without Kruise Leeming and Cameron Smith through suspension, while Harry Newman is ruled out with the hamstring injury which forced him off at Wakefield last time out.
They will have their eye on a second-successive win however, as they aim to climb the Betfred Super League table.
For Hull FC, Josh Reynolds and Jordan Lane miss out through injuries picked up last weekend, while Connor Wynne could miss the game with an arm injury..
But they will be boosted by the return of Joe Cator in Round 5 - he could make his first appearance of the season after a season-ending achilles injury suffered in 2021.
Friday - Wakefield Trinity v Toulouse Olympique - 7.30pm kick off
Reece Lyne returns from a two-game suspension this week, while fellow centre Corey Hall and hooker Liam Hood could also play after recovering from injury.
Morgan Escare has arrived at Wakefield on a two-week loan from Salford and could be a direct replacement for the suspended Max Jowitt, but Jacob Miller misses out.
Toulouse lost by just a point at home to Wigan last weekend and are still searching for their first-ever Super League win.
They have been boosted by the return of no fewer than four stars; Joseph Paulo, Dom Peyroux, Harrison Hansen and Andrew Dixon for Friday's trip to West Yorkshire.
Friday - Salford Red Devils v Hull KR - 7.45pm kick off
Sam Luckley comes in for Greg Burke and Tim Lafai is back after a week out as Salford aim to end their two-game losing streak at home to Hull KR.
For Rovers, who have one win from four at the start of the new season, Lachlan Coote misses out after suffering an injury against St Helens last time out, while Brad Takarangi has been stood down by the club.
Ethan Ryan comes into Tony Smith's squad for the first time since August 2021, while Rowan Milnes - who played on dual registration for Dewsbury Rams last week - and Kane Linnett are also amongst the 21-man squad.
Friday - St Helens v Warrington Wolves - 8pm kick off on Sky Sports
Curtis Sironen has completed a one-match ban and could come back into the side in place of the suspended Konrad Hurrell as the home side go in search of a fifth win from as many matches in 2022.
And youngster Jon Bennison joins the Saints 21-man squad, replacing Jake Wingfield.
For Warrington, who lost at home to Catalans Dragons last week, Josh Charnley and Matt Davis miss out through suspension, so it's a possible opportunity for Jack Darbyshire and Rob Butler in Friday night's big televised match.
Saturday - Huddersfield Giants v Castleford Tigers - 3.15pm kick off on Sky Sports
Castleford bring back former Giants stars Jake Mamo and Kenny Edwards after both recovered from injury, while Liam Watts bolsters their pack after completing a one-match ban for the Tigers, who collected their first win of the season last weekend - a 33-26 home win over Hull FC.
In opposition, Danny Levi returns after completing his two-match suspension, he's joined by Michael Lawrence in returning to the squad for Ian Watson's side.
But the away side on Saturday will have to run without the likes of international stars Theo Fages, Jake Wardle and Josh Jones who will miss the game through injury.
Catalans Dragons v Wigan Warriors (17.30 UK) - Sky Sports Arena
The second of a double-header of Betfred Super League action on Sky this Saturday sees Catalans welcome a host of players back into their 21-man squad.
Sam Tomkins, Dean Whare and Joe Chan all return after recovering from injury, while Michael McIlorum and Gil Dudson are also included for the tie with their former club after serving suspensions.
Wigan, who are one of two sides - alongside St Helens - still boasting a 100 per cent record in 2022, are unchanged from their hard-fought win at Toulouse last week.
The club have taken the opportunity to have a full week in France after last week's trip, but could welcome back Thomas Leuluai and Jake Bibby who missed out last weekend.
Betfred Super League Round 5 Fixtures:
Thursday
- Leeds Rhinos v Hull FC - 8pm - live on Sky Sports
Friday
- Wakefield Trinity v Toulouse Olympique - 7.30pm
- Salford Red Devils v Hull KR - 7.45pm
- St Helens v Warrington Wolves - 8pm - live on Sky Sports
Saturday
- Huddersfield Giants v Castleford Tigers - 3.15pm - live on Sky Sports
- Catalans Dragons v Wigan Warriors - 5.30pm [UK time] - live on Sky Sports