10th August 2017, 17:45 | Hull
The Black and Whites hold a two-point advantage over their top-four rivals in the Betfred Super League Super 8s table but have been beaten twice by Justin Holbrook's resurgent Saints.
St Helens hammered Hull 45-0 at Magic Weekend in Holbrook's first game in charge before edging Lee Radford's men 19-12 last month to launch a four-match winning run.
Another Saints victory at the Totally Wicked Stadium would take them above Hull into third place but Talanoa has warned that the Airlie Birds are highly motivated by those recent results.
"This will be a tough game," he said. "They've hit top form at the right time and climbed into the top four.
"The new coach has stepped in and he's got two up on us. It's a big game Friday night and we want to pay them back."
Ahead of his 100th Hull FC appearance, Fetuli Talanoa speaks to Hull FC Live pic.twitter.com/lKELtIwMpO— Hull FC (@hullfcofficial) August 10, 2017
Hull still have work to do to secure a top-four spot but Talanoa is aiming higher with six games to go.
"It would be hard for a side to come to Hull to play a semi with the support we have from our fans," he added.
"It's real important for us to get as many points as we can to finish in the top two and get a home semi.
"When one to 17 are all on for the whole 80 minutes we're a good team and a hard team to stop."
St Helens moved into the top four after ending Castleford Tigers' perfect home record in the opening round of the Super 8s.
The clash with Ladbrokes Challenge Cup finalists Hull represents another tough challenge but it is one Saints are relishing.
Holbrook said: "Hull are a good side. Having Gareth Ellis back in has stiffened them up in the forwards too.
"They are physical, dangerous and creative. They are in the cup final and sitting third because they are a good side.
"It will be a really hard game but it is one we are looking forward to. We have put ourselves in a good position so we want to keep that going."
Castleford remain overwhelming favourites to secure the League Leaders' Shield despite last week's setback.
The Tigers are eight points clear of second-placed Leeds Rhinos ahead of their trip to Salford Red Devils.
"When you lose you learn a lot about yourselves and your performance levels," said Castleford head coach Daryl Powell.
"We have been winning consistently for a number of weeks, so at some point you are going to get beat.
"I think we will learn a lot from it and we look forward to the challenges ahead."
The Red Devils are only a point adrift of the top four despite four straight defeats and three better off than both Huddersfield Giants and Wigan Warriors, who meet at the DW Stadium.
There has been nothing to separate the two sides this year after two draws and Giants head coach Rick Stone is expecting another tight contest.
"After their loss last week they will be stinging a little bit," said Stone.
"They understand that they can't drop too many points, similar to us, in the Super 8 series if they are to make the top four, so there is plenty at stake.
"Both teams have had pretty close games home and away this year and it makes for a good game."